The Role of Reactive Oxygen Species in Mitochondrial Permeability Transition
نویسندگان
چکیده
منابع مشابه
The role of reactive oxygen species in mitochondrial permeability transition.
We have provided evidence that mitochondrial membrane permeability transition induced by inorganic phosphate, uncouplers or prooxidants such as t-butyl hydroperoxide and diamide is caused by a Ca(2+)-stimulated production of reactive oxygen species (ROS) by the respiratory chain, at the level of the coenzyme Q. The ROS attack to membrane protein thiols produces cross-linkage reactions, that may...
متن کاملMitochondrial permeability transition in rat hepatocytes after anoxia/reoxygenation: role of Ca2+-dependent mitochondrial formation of reactive oxygen species.
Onset of the mitochondrial permeability transition (MPT) is the penultimate event leading to lethal cellular ischemia-reperfusion injury, but the mechanisms precipitating the MPT after reperfusion remain unclear. Here, we investigated the role of mitochondrial free Ca(2+) and reactive oxygen species (ROS) in pH- and MPT-dependent reperfusion injury to hepatocytes. Cultured rat hepatocytes were ...
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STUDY QUESTION Does mitochondrial permeability transition (MPT) induced by calcium overload cause reactive oxygen species (ROS) production and DNA fragmentation in human spermatozoa? SUMMARY ANSWER Studies conducted in vitro suggest that in human spermatozoa, MPT occurs in response to intracellular calcium increase and is associated with mitochondrial membrane potential (ΔΨm) dissipation, inc...
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We sought to understand the relationship between reactive oxygen species (ROS) and the mitochondrial permeability transition (MPT) in cardiac myocytes based on the observation of increased ROS production at sites of spontaneously deenergized mitochondria. We devised a new model enabling incremental ROS accumulation in individual mitochondria in isolated cardiac myocytes via photoactivation of t...
متن کاملthe immunopathogenic role of reactive oxygen species in alzheimer disease.
reactive oxygen species (ros) are produced in many normal and abnormal processes in humans, including atheroma, asthma, joint diseases, cancer, and aging. basal levels of ros production in cells could be related to several physiological functions including cell proliferation, apoptosis and homeostasis. however, excessive ros production above basal levels would impair and oxidize dna, ...
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ژورنال
عنوان ژورنال: Bioscience Reports
سال: 1997
ISSN: 0144-8463,1573-4935
DOI: 10.1023/a:1027335217774